Cure Alzheimer's FundTM has established a Research Consortium of leading Alzheimer's researchers and clinicians to guide and in some cases conduct research to be funded by the Cure Alzheimer's Fund. Our Research Roadmap is the product of agreement by members of the Research Consortium on the most expeditious route to slowing, stopping or reversing Alzheimer's disease.
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Novel Therapies for Alzheimer’s Disease Based on Easrly Onset Genes |
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Supplemental Information for Senate Special Committee on Aging Hearing Introduction Alzheimer’s disease (AD), the most common form of dementia, was first described roughly one hundred years ago in Bavaria by Dr. Alois Alzheimer in his presentation of an early-onset (<60 years) case. AD is a progressive and fatal neurodegenerative disease that impairs memory and overall cognition. There are more than 5 million documented patients according to best estimates, with some experts suggesting that may be only 20% of the total number actually affected. The number of new cases grows by more than 10% per year. Alzheimer’s disease is the seventh leading cause of death for people of all ages, the fifth leading cause of death in people age 65 and older, and is the only one of the major diseases (heart disease, breast and prostate cancer and stroke) to be increasing in mortality; up almost 33% from 2002 to 2004. Medicare expenditures for Alzheimer’s and other dementias in 2005 were $91 billion; this total is projected to increase to $160 billion by 2010. State and federal Medicaid spending for nursing home care for people with Alzheimer’s and other dementias was estimated at $21 billion in 2005, and is projected to increase to $24 billion by 2010. Given these estimates and no significant containment or decrease in Alzheimer’s, Medicaid and Medicare expenses for Alzheimer’s and related dementias will be approximately $184 billion by 2010, or approximately 27% of the entire combined anticipated expenditure for Medicare and Medicaid in 2010. |
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The Basics of Drug Discovery |
The path from research discovery to drug development can be a long one. Current estimates target the time for an Alzheimer’s drug to get to market at around 12 years. However, with new technological advances in such areas as genetics, we are optimistic that scientific opportunities have never been greater to reduce this timeline significantly. In his article, Dr. Tanzi highlights some of the promising developments on the immediate horizon. We’ve compiled the following background information on the drug development process in the United States to explain the progress of a drug to market. |
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