Selected Publications

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Lill CM, Bertram L , "Developing the ‘next generation’ of genetic association databases for complex diseases" , Hum. Mutat. , 33(9) , September 2012 , 1366–72
Lill CM, Liu T, Schjeide BM, Roehr JT, Akkad DA, Damotte V, Alcina A, Ortiz MA, Arroyo R, Lopez de Lapuente A, Blaschke P, Winkelmann A, Gerdes LA, Luessi F, Fernadez O, Izquierdo G, Antigüedad A, Hoffjan S, Cournu-Rebeix I, Gromöller S, Faber H, Liebsch M, Meissner E, Chanvillard C, Touze E, Pico F, Corcia P; ANZgene Consortium, Dörner T, Steinhagen-Thiessen E, Baeckman L, Heekeren HR, Li SC, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Fontaine B, Vandenbroeck K, Matesanz F, Urcelay E, Bertram L, Zipp F , "Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29,000 subjects" , J Med Genet. , 49(9) , September 2012 , 558-62
Wallace BC, Small K, Brodley CE, Lau J, Schmid CH, Bertram L, Lill CM, Cohen JT, Trikalinos TA , "Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining" , Genet Med. , 14(7) , July 2012 , 663-9
B.V. Hooli, PhD, G. Mohapatra, PhD, M. Mattheisen, MD, A.R. Parrado, PhD, J.T. Roehr, MS, Y. Shen, PhD, J.F. Gusella, PhD, R. Moir, PhD, A.J. Saunders, PhD, C. Lange, PhD, R.E. Tanzi, PhD and L. Bertram, MD , "Role of common and rare APP DNA sequence variants in Alzheimer disease" , Neurology 78 , 78/16 , April 17, 2012 , 1250-1257
Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB, Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP; 23andMe Genetic Epidemiology of Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium; Parkinson's Disease GWAS Consortium; Wellcome Trust Case Control Consortium 2), Young P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JP, Bertram L , "Comprehensive research synopsis and systematic meta-analyses in Parkinson’s disease genetics: The PDGene database" , PLoS Genet. , 8(3) , March 2012 , e1002548
Lill CM, Schjeide BM, Akkad DA, Blaschke P, Winkelmann A, Gerdes LA, Hoffjan S, Luessi F, Dörner T, Li SC, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Bertram L, Zipp F , "Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample" , Neurogenetics , 13(1) , February 2012 , 83-6
Sungho Wona, Qing Luc, Lars Bertram, Rudolph E. Tanzi, Christoph Lange , "On the Meta-Analysis of Genome-Wide Association Studies: A Robust and Efficient Approach to Combine Population and Family-Based Studies" , Human Heredity , 73 , January 18, 2012 , 35-46
Lebedeva E, Stingl JC, Thal DR, Ghebremedhin E, Strauss J, Özer E, Bertram L, von Einem B, Tumani H, Otto M, Riepe MW, Högel J, Ludolph AC, von Arnim CA , "Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD" , Neurobiol Aging , 33(1) , January 2012 , 201.e9-201.e18
Bertram L, Hampel H , "The role of genetics for biomarker development in neurodegeneration" , Prog Neurobiol. , 95(4) , December 2011 , 501-4
Lill CM, Bertram L , "Towards unveiling the genetics of neurodegenerative diseases" , Semin Neurol. , 31(5) , November 2011 , 531-41
Haworth A, Bertram L, Carrera P, Elson JL, Braastad CD, Cox DW, Cruts M, den Dunnen JT, Farrer MJ, Fink JK, Hamed SA, Houlden H, Johnson DR, Nuytemans K, Palau F, Rayan DL, Robinson PN, Salas A, Schüle B, Sweeney MG, Woods MO, Amigo J, Cotton RG, Sobrido MJ , "Call for participation in the neurogenetics consortium within the Human Variome Project" , Neurogenetics , 12(3) , August 2011 , 169-73
Bertram, L , "Alzheimer’s genetics in the GWAS era: a continuing story of ‘replications and refutations’" , Curr Neurol Neurosci Rep. , 11(3) , June 2011 , 246-53
Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M , "Cysteine 27 Variant of the δ-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking" , Mol Cell Biol. , 31(11) , June 2011 , 2326–2340
Thomas Pfeiffer, Lars Bertram, John P. A. Ioannidis , "Quantifying Selective Reporting and the Proteus Phenomenon for Multiple Datasets with Similar Bias " , Plos One , 6:3 , March 29, 2011
Brit-Maren M. Schjeide, BS; Cathrin Schnack, PhD; Jean-Charles Lambert, PhD; Christina M. Lill, MD; Julia Kirchheiner, MD, PhD; Hayrettin Tumani, MD; Markus Otto, MD; Rudolph E. Tanzi, PhD; Hans Lehrach, PhD; Philippe Amouyel, PhD; Christine A. F. von Arnim, MD; Lars Bertram, MD , "The Role of Clusterin, Complement Receptor 1, and Phosphatidylinositol Binding Clathrin Assembly Protein in Alzheimer Disease Risk and Cerebrospinal Fluid Biomarker Levels" , Arch Gen Psychiatry , 68(2) , February 7, 2011 , 207-213
Bertram L, Lill CM, Tanzi RE , "The Genetics of Alzheimer Disease: Back to the Future" , Neuron , 68(2) , Oct 21, 2010 , 270-81
Dolan SM, Hollegaard MV, Merialdi M, Betran AP, Allen T, Abelow C, Nace J, Lin BK, Khoury MJ, Ioannidis JP, Bagade S, Zheng X, Dubin RA, Bertram L, Velez Edwards DR, Menon R , "Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene)" , Public Health Genomics , 13(7-8) , May 20, 2010 , 514-23
Sleegers K, Lambert J-C, Bertram L, Cruts M, Amouyel P, Broeckhoven CV , "The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects" , Trends in Genetics , Volume 26, Issue 2 , February 2010 , 84-93
Castaldi PJ, Cho MH, Cohn M, Langerman F, Moran S, Tarragona N, Moukhachen H, Venugopal R, Hasimja D, Kao E, Wallace B, Hersh CP, Bagade S, Bertram L, Silverman EK, Trikalinos TA , "The COPD genetic association compendium: a comprehensive online database of COPD genetic associations" , Hum. Mol. Genet. , 10.1093/hmg/ddp519 , Feb 1, 2010
Giedraitis V, Glaser A, Sarajarvi T, Brundin R, Gunnarsson MD, Schjeide B-M, Tanzi RE, Helisalmi S, Pirttila T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M , "CALHM1 P86L polymorphism does not alter amyloid-β or tau in cerebrospinal fluid" , Neuroscience Letters , Volume 469, Issue 2 , Jan 22 2010 , 265-267
Lill CM, Bertram L , "Online databases and systematic meta-analyses of genetically complex diseases" , Medizin Genet , 22 , 2010 , 235-241
Won S, Bertram L, Becker D, Tanzi RE, Lange C. , "Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family - Based Association Tests" , Statistics in Biosciences , 1(2) , Nov 2009 , 125-143
Bertram, L, Tanzi RE , "Genome-wide association studies in Alzheimer's disease" , Human Molecular Genetics , Vol 18, Review Issue 2 , Oct 15, 2009
Bertram L , "Alzheimer's Disease Genetics: Current Status and Future Perspectives" , International Review of Neurobiology , Vol. 84 , 2009
Schjeide BM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, and Bertram L. , "Assessment of Alzheimer's disease case-control associations using family-based methods" , Neurogenetics , DOI 10.1007/s10048-008-1051-3, , Feb 10, 2009 , 568-580