Selected Publications

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Kim J, Eltorai AE, Jiang H, Liao F, Verghese PB, Kim J, Stewart FR, Basak JM, Holtzman DM , "Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis" , J Exp Med. , 209(12) , Nov 19, 2012 , 2149-56
Jee Hoon Roh,1,2,3 Yafei Huang,1 Adam W. Bero,1,2,3 Tom Kasten,1 Floy R. Stewart,1,2,3 Randall J. Bateman,1,2,3 David M. Holtzman1,2,3,4* , "Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of Amyloid-b in Mice with Alzheimer’s Disease Pathology" , Science Translational Medicine Home , Vol. 4, Issue 150 , September 5, 2012
Bero AW, Bauer AQ, Stewart FR, White BR, Cirrito JR, Raichle ME, Culver JP, Holtzman DM , "Bidirectional relationship between functional connectivity and amyloid-β deposition in mouse brain" , J Neurosci. , 32(13) , Mar 28, 2012 , 4334-40
Schwetye KE, Cirrito JR, Esparza TJ, Mac Donald CL, Holtzman DM, Brody DL , "Traumatic brain injury reduces soluble extracellular amyloid-β in mice: A methodologically novel combined microdialysis-controlled cortical impact study" , Neurobiology of Disease , Volume 40, Issue 3 , Dec 2010 , 555-564
Zeng C, Pan F, Jones LA, Lim MM, Griffin EA, Sheline YI, Mintun MA, Holtzman DM, Mach RH , "Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system" , Brain Research , Volume 1319 , Mar 10 2010 , 21-32
Clifford DB, Fagan AM, Holtzman DM, Morris JC, Teshome M, Shah AR, Kauwe JSK , "CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease" , Neurology , 73(23) , December 8, 2009 , 1982-7
Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM , "Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle" , Science , 326(5955) , Nov 13, 2009 , 1005-7
Yan P, Bero AW, Cirrito JR, Xiao Q, Hu X, Wang Y, Gonzales E, Holtzman DM, Lee J-M , "Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice" , The Journal of Neuroscience , 29(34) , Aug 26 2009 , 10706-10714
Andreas Åslund, Christina J. Sigurdson, Therése Klingstedt, Stefan Grathwohl, Tristan Bolmont, Dara L. Dickstein, Eirik Glimsdal, Stefan Prokop, Mikael Lindgren, Peter Konradsson, David M. Holtzman, Patrick R. Hof, Frank L. Heppner, Samuel Gandy, Mathias Jucker, Adriano Aguzzi, Per Hammarström and K. Peter R. Nilsson , "Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses" , Chemical Biology , 4:8 , July 22, 2009 , 673-684
Cao C, Cirrito JR, Lin X, Wang L, Verges DK, Dickson A, Mamcarz M, Zhang C, Mori T, Arendash GW, Holtzman DM, Potter H , "Caffeine suppresses beta-amyloid levels in plasma and brain of Alzheimer's transgenic mice." , Journal of Alzheimer's disease , July 2009
Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM , "Amyloid-beta dynamics correlate with neurological status in the injured human brain" , Science , 321(5893) , Aug 29, 2008 , 1221-4
Brody DL, Holtzman DM , "Active and Passive Immunotherapy for Neurodegenerative Disorders" , Annu Rev Neurosci. , 31 , July 2008 , 175–193
Cirrito JR, Kang J, Lee J, Stewart FR, Verges D, Silverio LM, Bu G, Mennerick S, Holtzman DM. , "Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo." , Neuron , 58(1) , April 10, 2008 , 42-51
Kang JE, Cirrito JR, Dong H, Csernansky JG, Holtzman DM , "Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity" , Neurology , Vol. 75/no. 7 , June 2007 , 595-602