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Lars Bertram, MD
Assistant Professor of Neurology, Assistant in Genetics
Harvard Medical School/Massachusetts General Hospital
Dr. Lars Bertram is Assistant Professor of Neurology, Assistant in Genetics at the Genetics and Aging Research Unit at Massachusetts General Hospital (MGH)/Harvard Medical School. At MGH, Dr. Bertram has spearheaded the analyses that led to the discovery of novel Alzheimer’s loci on chromosomes 9 & 10. His current research projects focus on searching and characterizing the putative Alzheimer’s genes underlying the loci identified in this and other studies. In collaboration with the Alzheimer Research Forum, Dr. Bertram developed and coordinated the “AlzGene database” project, a large-scale data mining effort in which his team has collected all of the nearly 1,000 published genetic association papers in the field. Using the same methodology, Dr. Bertram’s group this year launched two similar projects for genetic association studies of Parkinson’s disease (“PDGene”, funded by the Michael J. Fox Foundation), and schizophrenia (“SczGene”, funded by NARSAD). Together, these databases will allow interested scientists to find in one place detailed information about any gene that shows significant risk effects across a multitude of different study populations.
Project Description Researchers Funding Alz Research Forum for AlzGene Maintenance
Cure Alzheimer’s Fund is funding the upkeep and continued development of a revolutionary Web-based database. AlzGene is a fantastic resource for Alzheimer’s researchers, providing data and meta-analyses from hundreds of genetic association studies in an easy-to-use, searchable database. Scientists interested in a particular gene can search for it in AlzGene to see what previous studies have reported, receiving a wealth of information in a very short amount of time.
Lars Bertram, MD 2006 - 2012
Fine Mapping of Prioritized GWAS Results
In this application we propose to utilize next-generation sequencing combined with high-efficiency genomic sequence capture to systematically fine-map the 14q31 region which, based on the currently available data, very likely contains an important AD susceptibility locus(i). Newly identified variants will be followed up in more than 5,500 DNAs from both family-based and case-control backgrounds.
Lars Bertram, MD 2008
These published papers resulted from Cure Alzheimer’s Fund support."Call for participation in the neurogenetics consortium within the Human Variome Project" , Neurogenetics , 12(3) , August 2011 , 169-73,"Alzheimer’s genetics in the GWAS era: a continuing story of ‘replications and refutations’" , Curr Neurol Neurosci Rep. , 11(3) , June 2011 , 246-53,"Cysteine 27 Variant of the δ-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking" , Mol Cell Biol. , 31(11) , June 2011 , 2326–2340,"Quantifying Selective Reporting and the Proteus Phenomenon for Multiple Datasets with Similar Bias " , Plos One , 6:3 , March 29, 2011,"The Role of Clusterin, Complement Receptor 1, and Phosphatidylinositol Binding Clathrin Assembly Protein in Alzheimer Disease Risk and Cerebrospinal Fluid Biomarker Levels" , Arch Gen Psychiatry , 68(2) , February 7, 2011 , 207-213,"The Genetics of Alzheimer Disease: Back to the Future" , Neuron , 68(2) , Oct 21, 2010 , 270-81,"Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene)" , Public Health Genomics , 13(7-8) , May 20, 2010 , 514-23,"The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects" , Trends in Genetics , Volume 26, Issue 2 , February 2010 , 84-93,"The COPD genetic association compendium: a comprehensive online database of COPD genetic associations" , Hum. Mol. Genet. , 10.1093/hmg/ddp519 , Feb 1, 2010,"CALHM1 P86L polymorphism does not alter amyloid-β or tau in cerebrospinal fluid" , Neuroscience Letters , Volume 469, Issue 2 , Jan 22 2010 , 265-267,