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- In Memory
Zhongcong Xie, MD, Ph.D.
Mass General Hospital/Harvard
Funded in 2011 for work on "Surgery-induced Brain Inflammation Interacting With Genetic Mutation-Induced Elevated A-beta, Leading to Memory Impairment"
Project Description Researchers Funding General Anesthetics and Alzheimer’s Disease
The goal of this project is to test the hypothesis that desflurane is a safer anesthetic than isoflurane for AD patients in order to find safer anesthetics that won’t worsen AD symptoms.
Zhongcong Xie, MD, Ph.D. 2012
These published papers resulted from Cure Alzheimer’s Fund support."Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine." , J Neurosci , 28 , April 23, 2008 , 4551-60,"The Inhalation Anaesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Aβ Accumulation." , J. Neurosci. , 27 , 2007 , 1247-1254,