Posted: Sep. 20, 2013
In a paper just published in the prestigious journal Neuron, Harvard Medical School/Mass General Hospital Geneticist Dr. Rudy Tanzi, together with lead author, Dr. Jaehong Suh and their team, identified two rare mutations in the human gene called "ADAM10" that lead to the most common, late-onset variant of Alzheimer's. Tanzi's research suggests that the ADAM10 gene makes an enzyme called alpha-secretase, which cleaves the Amyloid Precursor Protein (APP) to prevent the formation of beta-amyloid, the toxic protein that triggers brain pathology in Alzheimer's disease.
Posted: Jun. 18, 2013
Research uncovering 12 new gene variations connected to the cause of the early-onset familial form of Alzheimer’s disease (EO-FAD), which generally strikes before the age of 65, is being published in the journal Molecular Psychiatry.
Posted: Feb. 13, 2013
Cure Alzheimer’s Fund is grateful to President Obama for the Administration’s continued commitment to curing Alzheimer’s disease. With the implementation of the first ever National Plan To End Alzheimer’s Disease, to which Cure Alzheimer’s Fund was a contributor, and his specific targeting of the disease last night in the State of the Union address, President Obama has highlighted a national resolve to defeat this disease.
During this webinar, David Shenk led a discussion with Rudy Tanzi, Ph.D., about the Whole Genome Sequencing project (WGS). Shenk and Tanzi covered the origins of Alzheimer’s genetics, the beginnings of WGS, the project’s expected impact on Alzheimer’s disease and the challenges going forward.
Posted: Oct. 18, 2012
Largest Single Private Investment in Alzheimer’s Whole Genome Sequencing Targets Effective Therapies and Cure: $5.4 Million Awarded for Research to Guide Alzheimer’s Drug Development
Understanding who is most susceptible to Alzheimer’s disease and developing early detection models, effective therapies and possibly a cure, is the goal of the largest single private scientific grant ever invested in Alzheimer’s Whole Genome Sequencing (WGS) focused on families afflicted with the disease.
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